Arli Aditya Parikesit - In Silico Molecular Interaction Studies of Suberoylanilide Hydroxamic Acid and Its Modified Compounds with Histones Deacetylase Class II **** sapiens as Curative Measure towards Cervical Cancer

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      Publication Details (including relevant citation   information):

      Usman Sumo Friend Tambunan, Arli Aditya Parikesit, Tirtana   Prasetia, Djati Kerami. Engineering, Vol.5 No.10B, October 2013

      Abstract:

      The threat of cervical cancer is a serious problem for the   women’s health. It is already known that the cause of cervical   cancer is definitely HPV (Human Papilloma Virus). The drug   development is the most reasonable approach for coping with HPV   infection. The development of HDACi (Histone Deacetylase   inhibitor) is seen as a feasible method for curing the threat of   cervical cancer. Rational drug design is our utilized pipeline   for drug development. The LigX MOE-based method has been   developed to investigate the molecular interaction of HDAC class   IIHomo sapienswith the designed lead compound. The method has   found that ligands 1c, 2a, and 2c are indeed feasible to be   formulated as drug candidates.

      Address (URL): http://www.scirp.org/journal/PaperInformation.aspx?PaperID=38836