Laura MacManus-Spencer - New Perspectives on Perfluorochemical Ecotoxicology: Inhibition and Induction of an Efflux Transporter in the Marine Mussel, Mytilus californianus.

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      Publication Details (including relevant citation   information): Stevenson, Charlotte N., MacManus-Spencer,   Laura A., Luckenbach, Till, Luthy, Richard G., Epel, David.,   Environ. Sci. Technol., 2006,   40 (17), pp 5580-5585

      Abstract: The toxicol. effects of perfluoroalkyl   acids on the p-glycoprotein (p-gp) cellular efflux transporter   were investigated using the marine mussel Mytilus californianus   as a model system. Four of the perfluoroalkyl acids studied   exhibit chemosensitizing behavior, significantly inhibiting p-gp   transporter activity. The inhibitory potency is maximal for the   longer chain acids perfluorononanoate (PFNA) and   perfluorodecanoate (PFDA), with av. IC50 values of 4.8 and 7.1   μM, resp. Results indicate that PFNA inhibits p-gp by an indirect   mechanism, and this inhibition is reversible and accompanied by a   rapid loss of PFNA from the tissue. In addn., PFNA induces   expression of the p-gp transporter after a 2-h exposure, a stress   response that may result in a metabolic cost to the organism.   Given that most organisms, including humans, share efflux   transporters as a first line of defense against toxicants, the   results of this study may have broader implications for the   ecotoxicol. of perfluoroalkyl acids. [on SciFinder(R)]

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