Publication Details (including relevant citation information): Cheng, Kai, Blumen, Steven R., MacPherson, Maximilian B., Steinbacher, Jeremy L., Mossman, Brooke T., Landry, Christopher C., ACS Appl. Mater. Interfaces, 2010, 2 (9), pp 2489-2495
Abstract: Strategies were developed by which mesoporous microparticles were modified on their external surfaces with tetraethylene glycol (TEG), a protein, or both, leaving the pore surfaces available for modification with a separate moiety, such as a dye. Only particles bifunctionally modified with both TEG and a cell-specific antibody were taken up specifically by a targeted cancer cell line. In contrast to similarly functionalized nanoparticles, endocytosed microparticles were not contained within a lysosome.
Address (URL): http://dx.doi.org/10.1021/am100530t