Christopher Lipinski - N-chlorination of dilantin and sorbinil

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      Publication Details (including relevant citation   information): Lipinski, Christopher A., Bordner, Jon,   Butterfield, Garth C., Marinovic, Lilian C., Journal of   Heterocyclic Chemistry, 1990, 27  (6), pp 1793-1799

      Abstract: The synthesis, stability, X-ray   structural characterization and 13C nmr shifts of N-1′,   N-3′-dichloro and N-1′-monochlorohydantoin derivatives of the   anticonvulsant dilantin and the aldose reductase inhibitor   sorbinil are described. These chlorinated derivatives may be   involved in drug induced hypersensitivity reactions.

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