Christopher Lipinski - Navigating chemical space for biology and medicine

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      Publication Details (including relevant citation   information): Lipinski, Christopher, Hopkins, Andrew,   Nature, 2004, 432 (7019), pp   855-861

      Abstract: Despite over a century of applying   organic synthesis to the search for drugs, we are still far from   even a cursory examination of the vast number of possible small   molecules that could be created. Indeed, a thorough examination   of all 'chemical space' is practically impossible. Given this,   what are the best strategies for identifying small molecules that   modulate biological targets? And how might such strategies   differ, depending on whether the primary goal is to understand   biological systems or to develop potential drugs?

      Address (URL): http://www.citeulike.org/user/TimRooney/article/3912