Publication Details (including relevant citation information): Lipinski, Christopher A., Craig, Rebecca H., Wright, Roger B., Journal of Heterocyclic Chemistry, 1985, 22 (6), pp 1723-1726
Abstract: The synthesis of the four possible 2-amino- and 2-guanidino- 4-(2-amino- and 2-guanidinothiazolyl)pyrimi-dines is described and pKa. values are calculated. Guanidinopyrimidines are more basic than guanidinothiazoles. However, the reverse is true of the corresponding amino heterocycles; the amino thiazole is more basic than the amino pyrimidine.