Vanraj Thakor - Synthesis and Anticancer activity of Flavone Derivatives against Estrogen Dependent Cancers by rational approach

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  Publication Details (including relevant citation   information):

  Vanraj   Thakor, J Kher, F Bhayani, B Atodaria, M Noolvi, Synthesis and   Anticancer activity of Flavone Derivatives against Estrogen   Dependent Cancers by rational approach, PharmaTutor, 2014, 2(2),   33-43

  Abstract:

  Aromatase and 17-ßHSD inhibitors are main target of   pharmacological interest for the treatment of

  estrogen dependent cancers. Chalcones, Coumarins, Flavones,   Isoflavones have been reported for such

  inhibition and are used for treatment of breast tumors. So in   this topic, Flavone derivatives containing

  Imidathiadiazole, Thiadiazole, Triazole and benzimidazole   hetrocycles synthesised by using simple

  laboratory reagents like 2-Hydroxy Acetophenone and 4-Hydroxy   Benzaldehyde to convert chalcone

  leads to formation of Flavones by cyclization using Microwave and   followed by attachment of different

  hetrocycles to form Flavone derivatives and characterized by IR,   1H NMR, 13C NMR spectroscopy and

  elemental analysis. These Flavone derivatives found to exhibit   moderate to high inhibitory activity

  against Estrogen dependent cancers.

  Address (URL): http://http://www.pharmatutor.org/magazines/articles/february-2014/synthesis-ant icancer-activity-flavone-derivatives-estrogen-dependent-cancers-rational-approac h

 

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