Publication Details (including relevant citation information):
Synthesis of fused indoles by sequential palladium-catalyzed Heck reaction and N-heteroannulation. Söderberg, Björn C. G.; Hubbard, Jeremiah W.; Rector, Stacey R.; O’Neil, Shannon N. Tetrahedron 2005, 61(15), 3637-3649
A route to 3,4-fused indoles via two consecutive palladium-catalyzed reactions; an intramolecular Heck reaction followed by a reductive N-heteroannulation is described. Using this route, a number of indoles have been prepared having a variety of ring sizes anchored to the 3- and 4-position of the indole nucleus. Furthermore, a number of functional groups, both carbon and heteroatom substituents can be introduced in (and on) the additional ring without any detrimental effects on the two reactions.
Address (URL): http://dx.doi.org/10.1016/j.tet.2005.02.033