Publication Details (including relevant citation information):
Org. Lett. 2013, 15, 736-739
The enantioselective syntheses of 10-hydroxylycopodine, deacetylpaniculine, and paniculine have been accomplished through use of a common intermediate. Key steps in the synthetic sequence toward these lycopodium alkaloids include formation of the tricyclic core via a conformationally accelerated, intramolecular Mannich cyclization and an organocatalyzed, intramolecular Michael addition to form the C7–C12 linkage.
Address (URL): http://pubs.acs.org/doi/abs/10.1021/ol303272w