Mrinmoy Saha - Toward a Unified Approach for the Lycopodines: Synthesis of 10-Hydroxylycopodine, Deacetylpaniculine, and Paniculine

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  Org. Lett. 2013, 15, 736-739


  The enantioselective syntheses of 10-hydroxylycopodine,   deacetylpaniculine, and paniculine have been accomplished through   use of a common intermediate. Key steps in the synthetic sequence   toward these lycopodium alkaloids include formation of the   tricyclic core via a conformationally accelerated, intramolecular   Mannich cyclization and an organocatalyzed, intramolecular   Michael addition to form the C7–C12 linkage.

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