Ann Newman - Critical Considerations in the Qualitative and Quantitative Determination of Process-Induced Disorder in Crystalline Solids

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      Publication Details (including relevant citation   information):

      A. Newman and G. Zografi. J Pharm Sci 2014, early view. DOI   10.1002/jps.23930


      Solid-state instabilities in crystalline solids arise during   processing primarily because a certain level of structural   disorder has been introduced into the crystal. Many physical   instabilities appear to be associated with the recrystallization   of molecules from these disordered regions, while chemical   instabilities arise from sufficient molecular mobility to allow   solid-state chemical reactivity. In this Commentary we discuss   the various forms of structural disorder, processing which can   produce disorder, the quantitative analysis of process-induced   order, and strategies to limit disorder and its effects.

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