Matthew Hartle - Chemically Reversible Reactions of Hydrogen Sulfide with Metal Phthalocyanines

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      Publication Details (including relevant citation   information):

      Inorg. Chem.

    DOI: 10.1021/ic500664c

    Publication Date (Web): May 1, 2014


        Hydrogen sulfide (H2S)   is an important signaling molecule that exerts action on various   bioinorganic targets. Despite this importance, few studies have   investigated the differential reactivity of the physiologically   relevant H2S   and HS    protonation states with metal complexes. Here we report the   distinct reactivity of H2S   and HS    with zinc(II) and cobalt(II) phthalocyanine (Pc) complexes and   highlight the chemical reversibility and cyclability of each   metal. ZnPc reacts with HS,   but not H2S,   to generate [ZnPc-SH],   which can be converted back to ZnPc by protonation. CoPc reacts   with HS,   but not H2S,   to form [CoIPc],   which can be reoxidized to CoPc by air. Taken together, these   results demonstrate the chemically reversible reaction of   HS    with metal phthalocyanine complexes and highlight the importance   of H2S   protonation state in understanding the reactivity profile of   H2S   with biologically relevant metal scaffolds.

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