Matteo Castronovo - DNA as Invisible Ink for AFM Nanolithography

Document created by Matteo Castronovo on Aug 22, 2014
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  Publication Details (including relevant citation   information): Liang, Jian, Castronovo, Matteo, Scoles,   Giacinto, 2011, 134 (1), pp 39-42

  Abstract: We have used nanografting, an atomic   force microscopy (AFM)-based nanolithography technique, to   fabricate thiolated DNA nanostructures on gold surfaces. The   tip-guided assembly offers opportunities for locally controlling   the packing order, density, and thus the thickness of the DNA   patterns. By selecting proper nanografting parameters, we can   embed single-stranded DNA (ssDNA) patches into a background   composed of the same DNA molecule prepared by self-assembly, in   which the patches remain topographically (and chemically)   invisible but have much improved packing order. When the   complementary DNA (cDNA) is added, the thickness of the   nanografted layer increases much more dramatically than that of   the self-assembled layer during the hybridization process, and as   a result, the pattern emerges. Interestingly, the pattern can be   reversibly hidden and shown with high fidelity simply by   dehybridizing and appending the cDNA repeatedly.

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