Ralf Haiges - Enantioselective synthesis of α-stereogenic γ-keto esters via formal umpolung.

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      Publication Details (including relevant citation   information): Prakash, G. K. Surya, Wang, Fang, Zhang,   Zhe, Ni, Chuanfa, Haiges, Ralf, Olah, George A., Org.   Lett., 2012, 14 (13), pp 3260-3263

      Abstract: A feasible method has been developed   for the enantioselective synthesis of α-stereogenic γ-keto   esters. By employing nitro(phenylsulfonyl)methane as an acyl   anion equiv., the integrated Michael addn. reaction-oxidative   methanolysis protocol allows the prepn. of various γ-keto esters   with high optical purities. [on SciFinder(R)]

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