Saleesh Kumar Nambalan Sivaraman - Fluorescent reporters of monoamine transporter distribution and function

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      Publication Details (including relevant citation   information):

     

     
        Authors    

          Sharanappa M Bagale, Adrienne S Brown, Melissa M Carballosa       Gonzalez, Alberto Vitores, Teresa L Micotto, NS Saleesh       Kumar, Ian D Hentall, James N Wilson    

     
     

     

     
        Publication date    

          2011/12/15    

     
     

     

     
        Journal name    

          Bioorganic & medicinal chemistry letters    

     
     

     

     
        Volume    

          21    

     
     

     

     
        Issue    

          24    

     
     

     

     
        Pages    

          7387-7391    

     
     

     

     
        Publisher    

          Pergamon    

     
     

     

     
        Description    

          Serotonin is a monoamine serving as a chemical messenger in       diverse brain regions, as
          well as in blood and various other organs. We synthesized six       ethylamine functionalized
          fluorophores as fluorescent probes for serotonin. The one       with best spectral properties and
          aqueous solubility, 6-amino-2-(2-aminoethyl)-1H-benzo [de]       isoquinoline-1, 3 (2H)-dione,
          was studied in detail both in vivo and in vitro. It was shown       to act as a ligand for serotonin
          transporter (SERT) without acute cerebral or cardiovascular       toxicity or adverse effects. ...   

     

     

     
       
          Total citations      

            Cited by 2     

       
     

      Abstract:

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