Saleesh Kumar Nambalan Sivaraman - Fluorescent reporters of monoamine transporter distribution and function

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  Publication Details (including relevant citation   information):

 

 
    Authors    

      Sharanappa M Bagale, Adrienne S Brown, Melissa M Carballosa       Gonzalez, Alberto Vitores, Teresa L Micotto, NS Saleesh       Kumar, Ian D Hentall, James N Wilson    

 
 

 

 
    Publication date    

      2011/12/15    

 
 

 

 
    Journal name    

      Bioorganic & medicinal chemistry letters    

 
 

 

 
    Volume    

      21    

 
 

 

 
    Issue    

      24    

 
 

 

 
    Pages    

      7387-7391    

 
 

 

 
    Publisher    

      Pergamon    

 
 

 

 
    Description    

      Serotonin is a monoamine serving as a chemical messenger in       diverse brain regions, as
      well as in blood and various other organs. We synthesized six       ethylamine functionalized
      fluorophores as fluorescent probes for serotonin. The one       with best spectral properties and
      aqueous solubility, 6-amino-2-(2-aminoethyl)-1H-benzo [de]       isoquinoline-1, 3 (2H)-dione,
      was studied in detail both in vivo and in vitro. It was shown       to act as a ligand for serotonin
      transporter (SERT) without acute cerebral or cardiovascular       toxicity or adverse effects. ...   

 

 

 
   
      Total citations      

        Cited by 2     

   
 

  Abstract:

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