Michelle Pillers - Electron-beam lithography and molecular liftoff for directed attachment of DNA nanostructures on silicon: Top-down meets bottom-up

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      Publication Details (including relevant citation   information):

      Acc. Chem. Res., 2014, 47 (6), pp 1759–1767   DOI: 10.1021/ar500001e


      Our work on lithographic patterning of DNA nanostructures was   inspired by a collaboration on molecular electronic devices known   as quantum-dot cellular automata or QCA. QCA is a paradigm for   computation in which information is transmitted and processed   through the interaction of coupled electrical charges or magnetic   dipoles. We began to explore the idea of molecular scale QCA and   found that ab initio methods, a thermodynamic Ising   model, and larger scale circuit design work suggested that   circuits that did computationally interesting things could   function at room temperature if made from molecular QCA cells of   chemically reasonable design.

      But how could the QCA cells be patterned to form the complex   arrays needed for computationally interesting circuitry, and how   could those arrays of molecular circuitry be integrated with   conventional electronic inputs and outputs? Top-down methods   lacked the spatial resolution and high level of parallelism   needed to make molecular circuits. Bottom-up chemical synthesis   lacked the ability to fabricate arbitrary and heterogeneous   structures tens to hundreds of nanometers in size. Chemical   self-assembly at the time could produce structures in the right   size scale, but was limited to homogeneous arrays. A potential   solution to this conundrum was just being demonstrated in the   late 1990s and early 2000s: DNA nanostructures self-assembled   from oligonucleotides, whose high information density could   handle the creation of arbitrary structures and chemical   inhomogeneity. Our group became interested in whether DNA   nanostructures could function as self-assembling circuit boards   for electrical or magnetic QCA systems. This Account focuses on   what we learned about the interactions of DNA nanostructures with   silicon substrates and, particularly, on how electron-beam   lithography could be used to direct the binding of DNA   nanostructures on a variety of functional substrates.

      Address (URL): http://pubs.acs.org/doi/abs/10.1021/ar500001e