Abdelouahab El-kharbachi - Tritium labeling of detonation nanodiamonds

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  Publication Details (including relevant citation   information):

  Girard, Hugues A., El-Kharbachi, Abdelouahab, Garcia-Argote,   Sebastien, Petit, Tristan, Bergonzo, Philippe, Rousseau, Bernard,   Arnault, Jean-Charles Chemical Communications  2014 50 (22) 2916-2918

  Abstract: For the first time, the radioactive   labeling of detonation nanodiamonds was efficiently achieved   using a tritium microwave plasma. According to our measurements,   the total radioactivity reaches 9120 +/- 120 [small mu ]Ci mg-1,   with 93% of 3H atoms tightly bonded to the surface and up to 7%   embedded into the diamond core. Such 3H doping will ensure highly   stable radiolabeled nanodiamonds, on which surface   functionalization is still allowed. This breakthrough opens the   way to biodistribution and pharmacokinetics studies of   nanodiamonds, while this approach can be scalable to easily treat   bulk quantities of nanodiamonds at low cost.

  Address (URL): http://dx.doi.org/10.1039/C3CC49653H