Bakhtiyor Rasulev - Towards understanding mechanisms governing cytotoxicity of metal oxides

Version 2

      Publication Details (including relevant citation   information):

      A Gajewicz, N Schaeublin, B Rasulev, S Hussain, D Leszczynska, T   Puzyn, J Leszczynski, Nanotoxicology, 2015, 9 (3), 313-325


        The production of nanomaterials increases every year   exponentially and therefore the probability these novel materials   that they could cause adverse outcomes for human health and the   environment also expands rapidly. We proposed two types of   mechanisms of toxic action that are collectively applied in a   nano-QSAR model, which provides governance over the toxicity of   metal oxide nanoparticles to the human keratinocyte cell line   (HaCaT). The combined experimental–theoretical studies allowed   the development of an interpretative nano-QSAR model describing   the toxicity of 18 nano-metal oxides to the HaCaT cell line,   which is a common in   vitro model   for keratinocyte response during toxic dermal exposure. The   comparison of the toxicity of metal oxide nanoparticles to   bacteriaEscherichia   coli (prokaryotic   system) and a human keratinocyte cell line (eukaryotic system),   resulted in the hypothesis that different modes of toxic action   occur between prokaryotic and eukaryotic systems.

      Address (URL): sms_Governing_Cytotoxicity_of_Metal_Oxides_Nanoparticles_Hints_from_Nano-QSAR_St udies