Daisuke Ishii - In Vivo Tissue Response and Degradation Behavior of PLLA and Stereocomplexed PLA Nanofibers

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  Publication Details (including relevant citation   information):

Biomacromolecules200910 (2), pp 237–242
DOI: 10.1021/bm8009363
Publication Date (Web): December 31, 2008


    Biocompatibility of PLLA and stereocomplexed PLA nanofibers was   evaluated by subcutaneous implantation in rats for 4−12 weeks.   Characterization of the nanofibers was performed by GPC, SEM,   wide-angle X-ray diffraction, and optical microscopy of   hematoxylin-eosin stained ultrathin sections of explanted   nanofibers. Stereocomplexed PLA nanofiber showed slower   degradation than PLLA nanofiber and thus retained their shape   after prolonged implantation. Furthermore, stereocomplexed PLA   nanofiber caused milder inflammatory reaction than PLLA   nanofiber. These results offer the potential use of PLLA and   stereocomplexed PLA nanofibers as a biomaterial for short-term   and long-term tissue regeneration, respectively. Stereocomplexed   PLA nanofiber after in vitro degradation showed smaller degree of   swelling than PLLA nanofiber. Taking the results of in vivo   degradation together with in vitro degradation into   consideration, bioabsorption mechanism of the in vivo degradation   of the nanofibers is proposed.

  Address (URL): http://pubs.acs.org/doi/abs/10.1021/bm8009363