Ebrahim Abouzari-Lotf - Eco-safe and expeditious approaches for synthesis of quinazoline and pyrimidine-2-amine derivatives using ionic liquids aided with ultrasound or microwave irradiation

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      Publication Details (including relevant citation   information):

      Zakeri, M., Nasef, M.M., Abouzari-Lotf, E. 199 267-274

      Abstract: Green approaches for efficient   synthesis of quinazoline- and pyrimidine-2-amine derivatives were   established based on the one-pot and three-component condensation   of guanidine carbonate, cyclic ketones and aldehydes. These   approaches involve the evaluation of the activity of several   acidic ionic liquids (ILs) as organocatalysts under solvent-free   medium in the microwave and as solvents and catalysts in the   ultrasound irradiations. Reactions were evaluated for a number of   substituted aldehydes and cyclic ketones on the basis of   variation of parameters including type and amount of ILs,   reaction temperature and time. Compared to the ultrasound method,   the solvent-free procedure in the microwave was found to be more   efficient in terms of both chemical yield and reaction time.   Catalyst recyclability, simplicity, and time-saving aspects of   the reaction suggests that these methods present real   alternatives to conventional reaction protocols. © 2014 Elsevier   B.V.

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