Ebrahim Abouzari-Lotf - A new one-pot synthesis of 1,2,4-oxadiazoles from aryl nitriles, hydroxylamine and crotonoyl chloride

Document created by Ebrahim Abouzari-Lotf on Aug 13, 2015
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  Publication Details (including relevant citation   information):

  Zakeri, M., Heravi, M.M., Abouzari-Lotf, E. 125 (4)   731-735

  Abstract: The reaction of aryl nitriles with   hydroxylamine using acetic acid as a catalyst followed by   subsequent addition of crotonoyl chloride to the intermediate   amidoxime represents a straightforward one-pot access to new   1,2,4-oxadiazole synthesis under mild conditions. The course of   the reaction was found to be high yielding and all new compounds   were well characterized by nuclear magnetic resonance (NMR), mass   spectrometry (MS) and elemental analysis. [Figure not available:   see fulltext.] © 2013 Indian Academy of Sciences.

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