David G. Calatayud - Metallic nanoparticles as synthetic building blocks for cancer diagnostics: from materials design to molecular imaging applications

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      Publication Details (including relevant citation   information):

      Mirabello, Vincenzo, Calatayud, David G., Arrowsmith, Rory L.,   Ge, Haobo, Pascu, Sofia I. J. Mater. Chem. B  2015 3 (28) 5657-5672

      Abstract: Metallic nanoparticles have been a   matter of intense exploration within the last decade due to their   potential to change the face of the medical world through their   role as ‘nanotheranostics’. Their envisaged capacity to act as   synthetic platforms for a multimodal imaging approach to   diagnosis and treatment of degenerative diseases, including   cancer, remains a matter of lively debate. Certain synthetic   metal-based nanomaterials, e.g. gold and iron oxide   nanoparticles, are already in clinical use or under advanced   preclinical investigations following in vitro and in vivo   preclinical imaging success. We surveyed the recent publications   landscape including those reported metallic nanoparticles having   established applications in vivo, as well as some of the new   metallic nanoparticles which, despite their potential as cancer   nanodiagnostics, are currently awaiting in vivo evaluation. The   objective of this review is to highlight the current metallic   nanoparticles and/or alloys as well as their derivatives with   multimodal imaging potential, focusing on their chemistry as a   springboard to discussing their role in the future of   nanomedicines design. We also highlight here some of the   fundamentals of molecular and nano-imaging techniques of   relevance to the metal-based colloids, alloys and metallic   nanoparticles discerning their future prospects as cancer   nanodiagnostics. The current approaches for metallic and alloy   surface derivatisation, aiming to achieve functional and   biocompatible materials for multimodal bioimaging applications,   are discussed in order to bring about some new perspectives on   the efficiency of metallic nanoparticles as synthetic scaffolds   for imaging probe design and forecast their future use in medical   imaging techniques (optical, CT, PET, SPECT and MRI).

      Address (URL): http://xlink.rsc.org/?DOI=C5TB00841G