Uttam Pal - Copper(I) oxide nanoparticle and tryptophan as its biological conjugate: a modulation of cytotoxic effects

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      Publication Details (including relevant citation   information):

      Maity, Mritunjoy, Pramanik, Sumit Kumar, Pal, Uttam, Banerji,   Biswadip, Maiti, Nakul Chandra 16 (1) 1-13

      Abstract: Recent investigations indicated that   copper oxide nanoparticles can selectively induce apoptosis and   effectively suppress the proliferation of tumor cells. Thus, it   showed a great potential to be used as a drug for cancer   treatment. Here we report an easy synthesis of spheroidal cuprous   oxide nanoparticles (CuNPs) and their organic conjugate with   l-tryptophan (Trp) using surfactant, sodium dodecyl sulfate as a   capping reagent. The particles looked golden yellow and showed a   strong affinity to bind blood carrier proteins such as bovine   serum albumin and human serum albumin. However, both optical   behavior and texture of the particles altered upon conjugation   with Trp. The average size of the CuNPs was estimated to be ~70   nm as appeared under transmission electron microscope or atomic   force microscope. The biological conjugate with Trp was ~85 nm   and looked light sky blue in aqueous suspension. The surface of   the conjugated nanoparticles was smoother than the bare CuNPs.   The CuNPs were found to be toxic to different cultured cancerous   cells; however, conjugation with Trp attenuated the toxicity, and   indicated its possible utility in developing a drug candidate for   cancer in a controlled fashion. Reduced toxicity also indicated a   possible use of the conjugated particle as a drug delivery   system.

      Address (URL): http://link.springer.com/article/10.1007/s11051-013-2179-z