Uttam Pal - Dipeptide derived from benzylcystine forms unbranched nanotubes in aqueous solution

Document created by Uttam Pal on Dec 25, 2015
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  Publication Details (including relevant citation   information):

  Banerji, Biswadip, Pramanik, Sumit Kumar, Pal, Uttam, Maiti,   Nakul Chandra 3 (1) 12-

  Abstract: The essence of modern nanotechnology   is manifested in the formation of well-ordered nanostructures by   a process of self-association. Peptides are among the most useful   building blocks for organic bionanostructures such as nanotubes,   nanospheres, nanotapes, nanofibrils, and other different ordered   structures at the nanoscale. Peptides are biocompatible,   chemically diverse, and much more stable and can be readily   synthesized on a large scale. Also, they have diverse application   in biosensors, tissue engineering, drug delivery, etc. Here, we   report a short cystine-based dipeptide, which spontaneously   self-associates to form straight, unbranched nanotubes. Such   self-assembled nanobiomaterials provide a novel possibility of   designing new functional biomaterials with potential applications   in nanobiotechnology. The formation of nanotubes in solution   state has been demonstrated by atomic force microscopy and   scanning electron microscopy. Infrared absorption and circular   dichroism demonstrated the intermolecular beta-sheet-like   backbone hydrogen bonding in juxtaposing and stacking of aromatic   side chains.

  Address (URL): http://www.jnanochem.com/content/3/1/12