David G. Calatayud - Labeling of Graphene, Graphene Oxides, and of Their Congeners: Imaging and Biosensing Applications of Relevance to Cancer Theranostics

Version 1

      Publication Details (including relevant citation   information):


      James A. Tyson, David G. Calatayud, Vincenzo Mirabello, Boyang   Mao, Sofia I. Pascu


      Advances in Inorganic   Chemistry 2016,   68, Chapter 9, 397-440


      Edited by Rudi van Eldik and Colin D. Hubbard


      ISBN: 978-0-12-803526-9





      The area of biomedical imaging is fast becoming an active focus   for the utilization of graphene within a variety of imaging   modalities. Graphene can be oxidized to produce a material with a   high degree of functionality and has led to its expansion as a   platform for the immobilization of fluorescent and radiolabeled   molecules. Its large surface area has allowed graphene and its   oxides to be modified with a variety of molecules that enhance   biocompatibility, selectivity, and therapeutic potential. This   chapter highlights recent developments in the use of targeted   fluorogenic or radiolabeled graphene materials that can be used   to image cancers via fluorescence, positron emission tomography,   and single-photon emission computed tomography modalities. Key   emphasis is placed on the nanocomposites that are designed to   provide additional therapeutic effects. The capacity of these   composites to be internalized by cells and tumors is discussed to   appreciate the future perspective of graphene and its congeners   as therapeutic multimodal imaging agents.

      Address (URL): http://dx.doi.org/10.1016/bs.adioch.2015.09.007