Publication Details (including relevant citation information):
Authors: Giovana B. Celli, Amyl Ghanem & Marianne Su-Ling Brooks
Critical Reviews in Food Science and Nutrition, DOI 10.1080/10408398.2015.1104290
Recent studies on the pharmacokinetics of anthocyanins (ACNs) and their metabolites have uncovered evidence for hitherto unknown physiological effects affecting the fate of these compounds in vivo. In particular, it has been shown that the stomach, in addition to the small intestine, has an important role in absorption. Most studies still use a non-compartmental or one-compartmental approach to determine the pharmacokinetic parameters of ACNs, which does not represent the anatomical and physiological conditions that a compound is subject to in the organism. Thus, the objective of this study was to review the current knowledge of the different processes involved in the metabolism of ACNs once ingested and, based on this information, propose a theoretical physiologically-based, multi-compartmental pharmacokinetic (PBPK) model to describe their fate in vivo. This is the first study that reports a PBPK model for ACNs; the model provides a more physiologically representative approach for ANC metabolism, which could be used as a basis for experimental designs and interspecies scale-up.