Giovana Celli - A theoretical physiologically-based pharmacokinetic approach for modelling the fate of anthocyanins in vivo

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      Authors: Giovana B. Celli, Amyl Ghanem & Marianne Su-Ling   Brooks

      Critical Reviews in Food Science and Nutrition, DOI   10.1080/10408398.2015.1104290


      Recent studies on the pharmacokinetics of anthocyanins (ACNs) and   their metabolites have uncovered evidence for hitherto unknown   physiological effects affecting the fate of these compounds in   vivo. In particular, it has been shown that the stomach, in   addition to the small intestine, has an important role in   absorption. Most studies still use a non-compartmental or   one-compartmental approach to determine the pharmacokinetic   parameters of ACNs, which does not represent the anatomical and   physiological conditions that a compound is subject to in the   organism. Thus, the objective of this study was to review the   current knowledge of the different processes involved in the   metabolism of ACNs once ingested and, based on this information,   propose a theoretical physiologically-based, multi-compartmental   pharmacokinetic (PBPK) model to describe their fate in vivo. This   is the first study that reports a PBPK model for ACNs; the model   provides a more physiologically representative approach for ANC   metabolism, which could be used as a basis for experimental   designs and interspecies scale-up.

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