Domonkos Feher - Highly Brominated Antimicrobial Metabolites from a Marine Pseudoalteromonas sp.

Version 1

      Publication Details (including relevant citation   information):

      Fehér,   Domonkos; Barlow, Russell; McAtee, Jesse; Hemscheidt, Thomas K.   Journal of Natural   Products 2010, 73, 1963-1966.

      Abstract:

       Extracts of a marine Pseudoalteromonas sp. (CMMED   290) isolated from the surface of a nudibranch collected in   Kaneohe Bay, Oahu, displayed significant antimicrobial activity   against methicillin-resistant Staphylococcus aureus.   Bioassay-guided fractionation of the lipophilic extract led to   the isolation and structure elucidation of two new highly   brominated compounds, 2,3,5,7-tetrabromobenzofuro[3,2-b]pyrrole   (1) and 4,4',6-tribromo-2,2'-biphenol (2). In addition, we have   identified the known compounds pentabromopseudilin and   bromophene. We describe the isolation and structure elucidation   of the compounds 1 and 2 together with their antimicrobial   activities against methicillin-resistant Staphylococcus   aureus.

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