Scott Jarmusch - Sarothrin from Alkanna orientalis is an antimicrobial agent and efflux pump inhibitor

Document created by Scott Jarmusch on Apr 7, 2016
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  Publication Details (including relevant citation   information):

  Bame, Jessica R, Graf, Tyler N, Junio, Hiyas A, Bussey, R Owen,   Jarmusch, Scott A, El-Elimat, Tamam, Falkinham, Joseph O,   Oberlies, Nicholas H, Cech, Richard A, Cech, Nadja B Planta   medica 2013 79 (5) 327-329

  Abstract: An Alkanna orientalis leaf and flower   extract inhibited the growth of Staphylococcus aureus, a pathogen   that causes an estimated 478,000 hospitalizations in the US   annually. Bioassay-guided fractionation of A. orientalis resulted   in isolation of the flavonoid sarothrin   (5,7,4′-trihydroxy-3,6,8-trimethoxyflavone), which inhibited the   growth of Mycobacterium smegmatis (MIC 75 μM) and S. aureus (MIC   >800 μM), and possessed efflux pump inhibitory activity. This   is the first report of antimicrobial or efflux pump inhibitory   activity of sarothrin, and of its presence in A. orientalis. Our   findings suggest that the effectiveness of A. orientalis extracts   is due to a combination of multiple constituents, including   sarothrin.

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