P Senthamil Selvan - Anti-Hyperlipidemic Activity of the Bark Extract of Terminalia Arjuna in Caffeine Induced Mice

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      Publication Details (including relevant citation   information):

      Volume : 5 | Issue : 8 | August 2015 | ISSN - 2249-555X

       

      P.SenthamilSelvan S.Velavan

      Research scholar of PG and Research Department   of Biochemistry,

      Maruthupandiyar College,

      Thanjavur,

      Tamil Nadu,

      India.

      Abstract:

      The present study was aimed to investigate the effect of bark   extract Terminalia Arjuna (2.4g/kg of body

      weight) on caffeine (150 mg/kg body weight) induced coronary   heart disease. Male Swiss albino mice

      weighing about 20 and 22g were used as the experimental animal   for the study. Caffeine dissolved in physiological

      saline (NaCl) with a pH of 7.0 administered orally to Swiss   albino mice continuously for about 14 days. Thereafter,

      all the animals sacrificed and the blood sample is collected for   all groups. The samples were estimated quantitative

      examinations of Low density lipoprotein cholesterol, Very low   density lipoprotein cholesterol, High density lipoprotein

      cholesterol, triglyceride and Total cholesterol. That the values   are compared against with Terminalia Arjuna treated animals.

      All the animals at the end of experiment showed significant   elevation in the level of cholesterol, LDL-cholesterol,

      VLDL-cholesterol and triglycerides and also a decrease level of   HDL-cholesterol (p<0.001). These finding suggest that

      the bark extract of Terminalia Arjuna has protective effects   against caffeine induced coronary heart disease and may

      have potential as a cardio protective agent

      Address (URL): http://www.ijar.in/