Elancheran Ramakrishnan - Polyphenol Rich Extract of Garcinia pedunculata Fruit Attenuates the Hyperlipidemia Induced by High Fat Diet

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      Publication Details (including relevant citation   information):

        Sarma R, Kumari S, Elancheran R, Deori M and Devi R (2016)  Front.   Pharmacol. 7:294. doi:   10.3389/fphar.2016.00294

      Abstract:

        Fatty foods, the most common diet today are the crux of many   metabolic disorders
      which need urgent attention.   Garcinia   pedunculata Roxb. (GP,   Clusiaceae) is a plant
      found available in Northeast (NE)   region of India, is considered to have versatile
      therapeutic properties. The people   of this region has been using dried pulp of GP
      fruit for the treatment of   different stomach related diseases traditionally. This study
      aimed at evaluating the potential   therapeutic action of the polyphenol-rich methanolic
      extract of the fruit in   experimental induced obese rats. In   vitro antioxidant   and
      antidiabetic activity of GP   extracts, i.e., fruit extract (GF) and seed extract (GS) were
      determined by using various   methods viz., 1,1-diphenyl-2 picrylhydrazyl (DPPH),   2,20-
      Azinobis (3-ethyl   benzthiazoline-6-sulphonic acid) (ABTS•+),   nitroblue tetrazolium (NBT)
      and α-glucosidase   inhibition assay for detection of antihyperglycemic activity.   In   vivo
      antilipidemic   and antiobesity activities were evaluated by administrating oral   dose of GF
      for 60 days on a high-fat diet   (HFD) induced hyperlipidemia in the rat. GF showed higher
      antioxidant activity than GS by   DPPH radical scavenging (IC50   = 4.01   µg/ml),   ABTS•+
      (IC50   = 0.82   µg/ml), NBT   (IC50 = 0.07   µg/ml) and   also showed notable α-glucosidase
      inhibitory activity   (IC50 = 19.26   µg/ml).   Furthermore, GF treated rat revealed a reduction
      in the body weight (60%),   serum total cholesterol (33%), triglycerides (32%), lowdensity   lipoprotein (38%) and liver biomarker enzymes after 60 days HFD   fed animals.
      Simultaneously, GF supplementation   significantly protected the HFD induced changes
      in hematological parameters.   Histological observations clearly differentiate the   structural
      changes in liver of HFD and GF   treated group. This novel dietary lipid adsorbing agent
      of GF exhibited prevention of   hyperlipidemia induced by HFD in the   rat.

      Address (URL): http://dx.doi.org/10.3389/fphar.2016.00294