Ivan Kempson - Mass Spectrometry Imaging of Pharmaceuticals: From Tablets to Tissues

Document created by Ivan Kempson on Sep 22, 2016
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  Publication Details (including relevant citation   information):

  Ivan Kempson and Clive Prestidge, Chapter 19, Mass Spectrometry   Imaging of Pharmaceuticals: From Tablets to Tissues, In   Analytical Techniques in the Pharmaceutical Sciences, Springer,   Eds: A Mullertz, Y Perrie and T Rades, Controlled Release   Society, 2016. DOI 10.1007/978-1-4939-4029-5_19


  Drug efficacy is dependent upon effective and controlled release   for delivery to the target site. The properties of a drug product   effecting delivery are carefully manipulated by a variety of   ingredients/excipients serving various purposes.
  As such, there is high dependence on the optimal construction and   spatial arrangement of all ingredients. The subsequent fate of   the active pharmaceutical ingredient then ultimately determines   therapeutic and toxic effects. Mass spectrometry imaging offers   high sensitivity, specificity, high mass resolution and high mass   ranges for imaging component distributions in solid forms and in   biological tissues. This chapter reviews mass spectrometry   imaging techniques most commonly utilised in these research   areas. Examples are then provided of imaging various    components in solid form products and on the exciting area of   label-free imaging of pharmaceuticals and metabolites in animal   tissues. A small section is also provided on micro-array imaging   of biologicals. Due to the relative immaturity of the field, a   special focus on future perspectives and emerging potential   concludes the chapter.

  Address (URL): http://link.springer.com/chapter/10.1007/978-1-4939-4029-5_19/fulltext.html