Publication Details (including relevant citation information):
Ivan Kempson and Clive Prestidge, Chapter 19, Mass Spectrometry Imaging of Pharmaceuticals: From Tablets to Tissues, In Analytical Techniques in the Pharmaceutical Sciences, Springer, Eds: A Mullertz, Y Perrie and T Rades, Controlled Release Society, 2016. DOI 10.1007/978-1-4939-4029-5_19
Drug efficacy is dependent upon effective and controlled release for delivery to the target site. The properties of a drug product effecting delivery are carefully manipulated by a variety of ingredients/excipients serving various purposes.
As such, there is high dependence on the optimal construction and spatial arrangement of all ingredients. The subsequent fate of the active pharmaceutical ingredient then ultimately determines therapeutic and toxic effects. Mass spectrometry imaging offers high sensitivity, specificity, high mass resolution and high mass ranges for imaging component distributions in solid forms and in biological tissues. This chapter reviews mass spectrometry imaging techniques most commonly utilised in these research areas. Examples are then provided of imaging various components in solid form products and on the exciting area of label-free imaging of pharmaceuticals and metabolites in animal tissues. A small section is also provided on micro-array imaging of biologicals. Due to the relative immaturity of the field, a special focus on future perspectives and emerging potential concludes the chapter.