Steven Stellman - Diesel exhaust exposure and mortality among males in the American Cancer Society prospective study

Document created by Steven Stellman on Dec 1, 2016
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  Boffetta, P., Stellman, S. D., Garfinkel, L. 14 (4)   403-15-

  Abstract: In 1982, the American Cancer Society   enrolled over 1.2 million American men and women in a prospective   mortality study of cancer and other causes in relation to   different risk factors. The 2-year mortality of 461,981 males   aged 40-79 years with known smoking habit has been analyzed in   relation to exposure to diesel exhaust (DE) and to employment in   selected occupations related to DE exposure. The relative risk   (RR) for all causes of death for those exposed was 1.05 (95%   confidence interval [CI]: 0.97-1.13). For lung cancer, the RR was   1.18 (95% CI: 0.97-1.44). A dose-response effect was present.   Railroad workers, heavy equipment operators, miners, and truck   drivers had a higher mortality both for all causes and for lung   cancer when compared with subjects with other occupations and no   exposure to DE. Truck drivers exposed to DE were not at excess   risk of lung cancer if compared with truck drivers unexposed to   DE, but a trend of increasing risk with duration of exposure was   suggested. DE exposure was also associated with increase in   mortality for accidents, cerebrovascular disease,   arteriosclerosis, and cirrhosis of the liver. An association   based on small numbers was also present for Hodgkin's disease and   lymphoid leukemia. No association with chronic non-neoplastic   pulmonary diseases or with bladder cancer was found.

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