Steven Stellman - A case-control study of multiple myeloma nested in the American Cancer Society prospective study

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      Boffetta, P., Stellman, S. D., Garfinkel, L. 43 (4)   554-9-

      Abstract: Among the subjects enrolled in the   American Cancer Society Cancer Prevention Study II, a large   nation-wide prospective study, 282 died from multiple myeloma   (MM) during the first 4 years of follow-up. These were divided   into incident cases who were initially free from disease and   prevalent cases who reported MM or related symptoms at the time   of enrollment. For each case, 4 controls matched for age, sex,   ethnic group and residence were randomly selected. Previous   history of diabetes [odds ratio (OR) = 2.0] and employment as   farmer (OR = 2.7) were the risk factors consistently suggested by   the results of the analysis. The risk associated with farming   showed a linear trend with duration of exposure. Pesticide or   herbicide exposure was not a risk factor per se but, when   combined with farming, it increased the OR to 4.3. Low education,   occupational exposure to dyes, and employment in a bank, on the   railroad or as a maid were also suggested risk factors, but   either they were not statistically significant or they were based   on small numbers of exposed subjects. No association between MM   and asbestos exposure was observed.

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