Steven Stellman - The "over-exposed" control group

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      Publication Details (including relevant citation   information):

      Wynder, E. L., Stellman, S. D. 135 (5) 459-61-

      Abstract: Relative risk is determined as much by   the level of exposure among controls as among cases. If cases and   controls are drawn from a population in which the range of   exposures is narrow, then a study may yield little information   about potential health effects. This may be one reason why an   association between dietary fat and cancer has not been   consistently observed in Western populations. Since the fat   intake as a percent of total calories in the US general   population varies little, only very large relative risks can be   detected in epidemiologic studies. Investigators of the dietary   fat hypothesis need to select study groups from populations where   the risk factor is not, essentially, narrowly distributed.

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