Steven Stellman - Relation between exposure to environmental tobacco smoke and lung cancer in lifetime nonsmokers

Document created by Steven Stellman on Dec 1, 2016
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  Publication Details (including relevant citation   information):

  Kabat, G. C., Stellman, S. D., Wynder, E. L. 142 (2)   141-8-

  Abstract: To assess the relation between   exposure to environmental tobacco smoke throughout life and lung   cancer in lifetime nonsmokers, the authors conducted in-person   interviews with 41 male and 69 female never-smoking lung cancer   cases and 117 male and 187 female never-smoking controls between   1983 and 1990 as part of a hospital-based case-control study of   tobacco-related cancers. Cases had newly diagnosed,   histologically confirmed primary carcinoma of the lung. Controls   were matched to cases on age (+/- 5 years), sex, race, hospital,   and year of interview. Subjects were asked about environmental   tobacco smoke exposure in childhood, in adulthood at home, in   different jobs, and in transportation and social situations. In   addition to amount smoked by family members in the subject's   presence, subjects were asked to rate the intensity of each   exposure, and married subjects were asked whether their spouse   smoked in the bedroom. Several independent indicators of exposure   to smoking by spouses were strongly correlated, thereby   increasing confidence in the classification of exposure status.   The reproducibility of environmental tobacco smoke variables was   good for qualitative measures (yes/no), in agreement with   previous studies. There were few associations of exposure in   specific settings with lung cancer. Males whose wives smoked had   odds ratio of 1.60 (95% confidence interval (CI) 0.67-3.82) and   females whose husbands smoked had an odds ratio of 1.08 (95% CI   0.60-1.94). While this study had limited sample size, the pattern   of odds ratios shows little indication of an association of   environmental tobacco smoke with lung cancer in nonsmokers.

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