Steven Stellman - Smoking and pancreatic cancer in men and women

Document created by Steven Stellman on Dec 1, 2016
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  Muscat, J. E., Stellman, S. D., Hoffmann, D., Wynder, E. L.   6 (1) 15-9-

  Abstract: Most studies of smoking and pancreatic   cancer have used male subjects or combined men and women together   in statistical analyses. There is little information on the   relative risk of smoking and pancreatic cancer in women. Because   of the high case-fatality rate, many of these studies were also   based on information gathered from proxy respondents, in which   smoking habits may not be recalled with certainty. A   hospital-based study of 484 male and female patients with   pancreatic cancer and 954 control subjects was conducted based on   direct interviews of incident cases. Compared to never smokers,   the odds ratio (OR) for current cigarette smokers was 1.6 [95%   confidence interval (CI), 1.1-2.4] for men and 2.3 (95% CI,   1.4-3.5) for women. In women, but not in men, there was a trend   in the ORs with years of daily cigarette consumption (P <   0.01). Filter cigarettes offered no protective advantage compared   to nonfilter cigarettes. Among men, the OR was 2.1 (95% CI,   1.2-3.8) for pipe/ cigar smokers and 3.6 (95% CI, 1.0-12.8) for   tobacco chewers. Tobacco smoke causes pancreatic cancer when   inhaled into the lungs. Tobacco juice may also cause pancreatic   cancer when ingested or absorbed through the oral cavity. These   data suggest that smoking is a cause of pancreatic cancer in   women and that the risks for female smokers are comparable to   male smokers. Nevertheless, the causes of most pancreatic cancers   are unknown.

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