Steven Stellman - Cigarette smoking and large cell carcinoma of the lung

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      Publication Details (including relevant citation   information):

      Muscat, J. E., Stellman, S. D., Zhang, Z. F., Neugut, A. I.,   Wynder, E. L. 6 (7) 477-80-

      Abstract: Large cell carcinoma is the fourth   most common histological type of lung cancer in the United   States. Cigarette smoking causes large cell lung cancer, but it   is uncertain whether the effect varies with the amount and   duration of smoking. This uncertainty stems from ambiguity in the   histopathological classification of large cell cancer, especially   before 1971, and the relatively infrequent occurrence of large   cell cancer in epidemiological studies. The present case-control   investigation demonstrates that the risk of large cell cancer   increases with both the frequency and number of years of   cigarette smoking. The odds ratio associated with smoking two or   more packs/day was 37.0 (95% confidence interval, 16.4-83.2) in   men and 72.9 (35.4-150.2) in women. It is concluded that   cigarette smoking is the predominant cause of large cell lung   cancer.

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