Steven Stellman - Impact of filter cigarette smoking on lung cancer histology

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      Publication Details (including relevant citation   information):

      Stellman, S. D., Muscat, J. E., Hoffmann, D., Wynder, E. L.   26 (4) 451-6-

      Abstract: BACKGROUND: The rates of lung   adenocarcinoma cancer have risen more rapidly than the rates of   lung squamous cell cancer over the past 2 decades. METHODS: A   case-control study was carried out to assess the impact of   long-term filter cigarette smoking on the risk of squamous cell   carcinoma (SCC) and adenocarcinoma (AC) of the lung. RESULTS:   Odds ratios for SCC among subjects who had smoked only filter   cigarettes were reduced relative to lifetime nonfilter cigarette   smokers by 30% for men and by 60% for women, but no risk   reduction was observed for AC of the lung. CONCLUSION: The   predominance of AC over SCC may be due in part to the fact that   smokers of very low yield cigarettes tend to compensate for the   lower nicotine levels by inhaling more deeply and frequently,   leading to greater exposure of the peripheral lung to the   carcinogens in tobacco smoke, and in part to the increased   concentration of nitrosamines that preferentially produce AC in   laboratory animals.

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