Steven Stellman - Cancer mortality and wood dust exposure among participants in the American Cancer Society Cancer Prevention Study-II (CPS-II)

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      Stellman, S. D., Demers, P. A., Colin, D., Boffetta, P.   34 (3) 229-37-

      Abstract: In 1994, the International Agency for   Research on Cancer (IARC) classified wood duct as a human   carcinogen, based on very strong evidence of a carcinogenic risk   of sino-nasal cancer. Excesses of other cancers, including lung   and stomach, have been reported among persons employed in wood   industries or occupationally exposed to wood dust, but not as   consistently. We investigated such possible associations using   the mortality experience of 362,823 men enrolled in the American   Cancer Society's Cancer Prevention Study-II in 1982 and followed   up for 6 years. Within this group, 45,399 men (12.5%) reported   either employment in a wood-related occupation or exposure to   wood dust or both. Among woodworkers, a small but significant   excess risk was found for all cases of death (RR 1.17 (95% CI   1.11-1.24)) and for total malignancies (RR 1.17 (1.05-1.30)).   Among men who reported exposure to wood dust, there was an   elevated risk of total mortality (Rr 1.07 (1.03-1.11)), total   malignancies (RR 1.08 (1.01-1.15)), and lung cancer (RR 1.17   (1.04-1.31)). Among woodworkers, a significant trend (P = 0.02)   of increasing risk of lung cancer with increasing duration of   exposure was observed. An unexpected, significantly increased   mortality from prostate cancer was observed in both wood-employed   and wood-exposed, and a twofold increased risk of fatal brain   cancer was seen among the former. Lung cancer mortality was   especially high among woodworkers who also reported exposure to   asbestos or formaldehyde, and it appears that exposure to these   known carcinogens may partly explain the observed increased   risks. Excess sino-nasal cancer was not observed, but the number   of cases was small.

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