Steven Stellman - Relative abundance of organochlorine pesticides and polychlorinated biphenyls in adipose tissue and serum of women in Long Island, New York

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      Stellman, S. D., Djordjevic, M. V., Muscat, J. E., Gong, L.,   Bernstein, D., Citron, M. L., White, A., Kemeny, M., Busch, E.,   Nafziger, A. N. 7 (6) 489-96-

      Abstract: Some organochlorine pesticides (OCPs)   and PCBs are under investigation as possible risk factors for   breast cancer because of their estrogenic properties and   widespread presence in the environment. It is important to know   whether adipose tissue used by some investigators and serum   assays used by others can provide comparable information on body   burden. Concentrations of seven OCPs or their breakdown products   as well as 14 PCB congeners were measured in the adipose tissue   and serum of 293 women enrolled as controls in a case-control   study of environmental factors for breast cancer in Long Island,   New York, a high-risk region. Adipose OCP/PCB levels were   measured using a supercritical fluid extraction method developed   by the authors. 1,1-Dichloro-2,2-di(4-chlorophenyl)ethylene   (p,p'-DDE) was detected in all adipose and serum samples; two   chlordane derivatives, beta-hexachlorocyclohexane (a lindane   isomer) and hexachlorobenzene, were detected in at least 92% of   adipose samples. The di-ortho hexachlorinated PCB congeners   2,4,5,2',4',5'-hexachlorobiphenyl and   2,3,4,2',4',5'-hexachlorobiphenyl were detected in all adipose   and over 98% of serum samples.   1,1-Dichloro-2,2-di(4-chlorophenyl)ethylene comprised 77% of   total pesticide residues in adipose and 71% in serum.   2,4,5,2',4',5'-Hexachlorobiphenyl comprised 24% of adipose and   21% of serum PCBs. The relative concentration patterns of the 14   PCB congeners were similar to those reported in other human   studies and were also typical of patterns reported in   environmental samples from various biota, including mammals and   birds, but differed substantially from patterns reported in   occupationally exposed workers. All adipose-serum correlations   for pesticides and most PCBs were statistically significant.   Either serum or adipose OCP/PCB levels of a variety of   environmental organochlorine compounds may serve as useful   biomarkers of body burden.

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