Steven Stellman - Handheld cellular telephone use and risk of brain cancer

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      Publication Details (including relevant citation   information):

      Muscat, J. E., Malkin, M. G., Thompson, S., Shore, R. E.,   Stellman, S. D., McRee, D., Neugut, A. I., Wynder, E. L.   284 (23) 3001-7-

      Abstract: CONTEXT: A relative paucity of data   exist on the possible health effects of using cellular   telephones. OBJECTIVE: To test the hypothesis that using handheld   cellular telephones is related to the risk of primary brain   cancer. DESIGN AND SETTING: Case-control study conducted in 5 US   academic medical centers between 1994 and 1998 using a structured   questionnaire. PATIENTS: A total of 469 men and women aged 18 to   80 years with primary brain cancer and 422 matched controls   without brain cancer. MAIN OUTCOME MEASURE: Risk of brain cancer   compared by use of handheld cellular telephones, in hours per   month and years of use. RESULTS: The median monthly hours of use   were 2.5 for cases and 2.2 for controls. Compared with patients   who never used handheld cellular telephones, the multivariate   odds ratio (OR) associated with regular past or current use was   0.85 (95% confidence interval [CI], 0.6-1.2). The OR for   infrequent users (<0. 72 h/mo) was 1.0 (95% CI, 0.5-2.0) and   for frequent users (>10.1 h/mo) was 0.7 (95% CI, 0.3-1.4). The   mean duration of use was 2.8 years for cases and 2.7 years for   controls; no association with brain cancer was observed according   to duration of use (P =.54). In cases, cerebral tumors occurred   more frequently on the same side of the head where cellular   telephones had been used (26 vs 15 cases; P =.06), but in the   cases with temporal lobe cancer a greater proportion of tumors   occurred in the contralateral than ipsilateral side (9 vs 5   cases; P =.33). The OR was less than 1.0 for all histologic   categories of brain cancer except for uncommon   neuroepitheliomatous cancers (OR, 2.1; 95% CI, 0.9-4.7).   CONCLUSIONS: Our data suggest that use of handheld cellular   telephones is not associated with risk of brain cancer, but   further studies are needed to account for longer induction   periods, especially for slow-growing tumors with neuronal   features.

      Address (URL): http://www.ncbi.nlm.nih.gov/pubmed/11122586