Steven Stellman - Role of polymorphisms in codons 143 and 160 of the O6-alkylguanine DNA alkyltransferase gene in lung cancer risk

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      Kaur, T. B., Travaline, J. M., Gaughan, J. P., Richie, J. P.,   Jr., Stellman, S. D., Lazarus, P. 9 (3) 339-42-

      Abstract: O6-Alkylguanine DNA alkyltransferase   (AGT) plays an important role in the repair of alkylating   agent-induced DNA damage and protection from the carcinogenic   effects of environmental agents. To examine the importance of the   AGT codon 143 and codon 160 polymorphisms in risk for lung cancer   and to assess the prevalence of these polymorphisms in different   racial groups, we performed genotype analysis of lung cancer   patients and matched controls. The prevalence of the AGT143Val   allele in controls was 0.07 in Caucasians and 0.03 in African   Americans. The AGT143Val allele was not detected in an unmatched   Asian control cohort. The prevalence of the AGT160Arg variant   allele was 0.01 in Caucasians, 0.02 in African Americans, and   0.03 in Asians. A marginally significant association was observed   between the AGT codon 143 (isoleucine/valine) genotype and risk   for lung cancer (odds ratio = 2.1; 95% confidence interval =   1.01-4.7). The prevalence of the AGT160Arg variant allele was   similar in lung cancer cases versus matched controls. These   results suggest that the AGT codon 143 polymorphism may play an   important role in risk for lung cancer.

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