Steven Stellman - Breast cancer risk in relation to adipose concentrations of organochlorine pesticides and polychlorinated biphenyls in Long Island, New York

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      Stellman, S. D., Djordjevic, M. V., Britton, J. A., Muscat, J.   E., Citron, M. L., Kemeny, M., Busch, E., Gong, L. 9  (11) 1241-9-

      Abstract: To assess a possible etiological role   of organochlorine compounds in breast cancer development on Long   Island, a high-risk region of New York State, concentrations of   organochlorine pesticides and polychlorinated biphenyls (PCBs)   were measured in the adipose tissue of 232 women with breast   cancer and 323 hospital controls admitted to surgery for benign   breast disease or non-breast-related conditions. Seven pesticide   residues and 14 PCB congeners were assayed via a supercritical   fluid extraction method followed by gas chromatography with   electron capture detection. After adjustment for age and body   mass index, which were strongly correlated with organochlorine   levels, adipose concentrations of   1,1-dichloro-2,2-di(4-chlorophenyl)ethylene, total pesticides,   and total polychlorinated biphenyls (PCBs) did not differ   significantly between cases and controls. The relative abundance   of individual pesticide species and PCB congeners was similar in   cases and controls. Odds ratios adjusted for age, BMI, hospital,   and race gave no evidence of a dose-response for   1,1-dichloro-2,2-di(4-chlorophenyl)ethylene, total pesticides, or   total PCBs, whether stratified by estrogen receptor status or   not. Breast cancer risk among Long Island residents was not   elevated compared with residents of the adjacent New York City   borough of Queens. We did not confirm a previously reported   association between breast cancer risk and levels of PCB congener   118 (2,3',4,4',5-pentachlorobiphenyl), nor did we observe an   association with the most abundant congener 153   (2,2',4,4',5,5'-hexachlorobiphenyl), a strong inducer of phase I   enzymes that was reported recently to have estrogenic properties.   Only PCB congener 183 (2,2',3,4,4',5',6-heptachlorobiphenyl),   which is also an inducer, was significantly associated with risk,   with an adjusted odds ratio of 2.0 (95% confidence interval,   1.2-3.4) in women with adipose levels >5.67 ng/g; the   biological importance of this observation is unclear without   confirmation in additional studies. Although neither the present   nor other studies have provided convincing evidence of an   association between body burden of   1,1,1-trichloro-2,2-bis(4-chlorophenyl)ethane and PCBs with   cancer of the breast, these compounds are rated as "possible" and   "probable" human carcinogens, respectively, by the International   Agency for Research on Cancer. Investigations of associations   with cancer at other sites should be carried out.

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