Steven Stellman - The Long Island Breast Cancer Study Project: description of a multi-institutional collaboration to identify environmental risk factors for breast cancer

Document created by Steven Stellman on Dec 1, 2016
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  Gammon, M. D., Neugut, A. I., Santella, R. M., Teitelbaum, S. L.,   Britton, J. A., Terry, M. B., Eng, S. M., Wolff, M. S., Stellman,   S. D., Kabat, G. C., Levin, B., Bradlow, H. L., Hatch, M., Beyea,   J., Camann, D., Trent, M., Senie, R. T., Garbowski, G. C.,   Maffeo, C., Montalvan, P., Berkowitz, G. S., Kemeny, M., Citron,   M., Schnabe, F., Schuss, A., Hajdu, S., Vincguerra, V., Collman,   G. W., Obrams, G. I. 74 (3) 235-54-

  Abstract: The Long Island Breast Cancer Study   Project is a federally mandated, population-based case-control   study to determine whether breast cancer risk among women in the   counties of Nassau and Suffolk, NY, is associated with selected   environmental exposures, assessed by blood samples, self-reports,   and environmental home samples. This report describes the   collaborative project's background, rationale, methods,   participation rates, and distributions of known risk factors for   breast cancer by case-control status, by blood donation, and by   availability of environmental home samples. Interview response   rates among eligible cases and controls were 82.1% (n = 1,508)   and 62.8% (n = 1,556), respectively. Among case and control   respondents who completed the interviewer-administered   questionnaire, 98.2 and 97.6% self-completed the food frequency   questionnaire; 73.0 and 73.3% donated a blood sample; and 93.0   and 83.3% donated a urine sample. Among a random sample of case   and control respondents who are long-term residents, samples of   dust (83.6 and 83.0%); soil (93.5 and 89.7%); and water (94.3 and   93.9%) were collected. Established risk factors for breast cancer   that were found to increase risk among Long Island women include   lower parity, late age at first birth, little or no breast   feeding, and family history of breast cancer. Factors that were   found to be associated with a decreased likelihood that a   respondent would donate blood include increasing age and past   smoking; factors associated with an increased probability include   white or other race, alcohol use, ever breastfed, ever use of   hormone replacement therapy, ever use of oral contraceptives, and   ever had a mammogram. Long-term residents (defined as 15+ years   in the interview home) with environmental home samples did not   differ from other long-term residents, although there were a   number of differences in risk factor distributions between   long-term residents and other participants, as anticipated.

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