Steven Stellman - Environmental toxins and breast cancer on Long Island. II. Organochlorine compound levels in blood

Version 1

      Publication Details (including relevant citation   information):

      Gammon, M. D., Wolff, M. S., Neugut, A. I., Eng, S. M.,   Teitelbaum, S. L., Britton, J. A., Terry, M. B., Levin, B.,   Stellman, S. D., Kabat, G. C., Hatch, M., Senie, R., Berkowitz,   G., Bradlow, H. L., Garbowski, G., Maffeo, C., Montalvan, P.,   Kemeny, M., Citron, M., Schnabel, F., Schuss, A., Hajdu, S.,   Vinceguerra, V., Niguidula, N., Ireland, K., Santella, R. M.   11 (8) 686-97-

      Abstract: Whether environmental contaminants   increase breast cancer risk among women on Long Island, NY, is   unknown. The study objective is to determine whether breast   cancer risk is increased in relation to organochlorines,   compounds with known estrogenic characteristics that were   extensively used on Long Island and other areas of the United   States. Recent reports do not support a strong association,   although there are concerns with high risks observed in subgroups   of women. Blood samples from 646 case and 429 control women from   a population-based case-control study conducted on Long Island   were analyzed. No substantial elevation in breast cancer risk was   observed in relation to the highest quintile of lipid-adjusted   serum levels of p,p'-bis(4-chlorophenyl)-1,1-dichloroethene (DDE)   [odds ratio (OR), 1.20 versus lowest quintile; 95% confidence   interval (CI), 0.76-1.90], chlordane (OR, 0.98; 95% CI,   0.62-1.55), dieldrin (OR, 1.37; 95% CI, 0.69-2.72), the sum of   the four most frequently occurring PCB congeners (nos. 118, 153,   138, and 180; OR, 0.83; 95% CI, 0.54-1.29), and other PCB   congener groupings. No dose-response relations were apparent. Nor   was risk increased in relation to organochlorines among women who   had not breastfed or were overweight, postmenopausal, or   long-term residents of Long Island; or with whether the case was   diagnosed with invasive rather than in situ disease, or with a   hormone receptor-positive tumor. These findings, based on the   largest number of samples analyzed to date among primarily white   women, do not support the hypothesis that organochlorines   increase breast cancer risk among Long Island women.

      Address (URL): http://www.ncbi.nlm.nih.gov/pubmed/12163320