Steven Stellman - Monitoring the tobacco use epidemic II: The agent: Current and emerging tobacco products

Version 1

      Publication Details (including relevant citation   information):

      Stellman, S. D., Djordjevic, M. V. 48 (1 Suppl) S11-5-

      Abstract: OBJECTIVE: This Agent paper (II of V   on monitoring the tobacco use epidemic) summarizes the findings   and recommendations of the Agent (product) Working Group of the   November, 2002, National Tobacco Monitoring, Research and   Evaluation Workshop. METHODS: The Agent Working Group evaluated   the need to develop new surveillance systems for quantifying   ingredients and emissions of tobacco and tobacco smoke and to   improve methods to assess uptake and metabolism of these   constituents taking into account variability in human smoking   behavior. RESULTS: The toxic properties of numerous tobacco and   tobacco smoke constituents are well known, yet systematic   monitoring of tobacco products has historically been limited to   tar, nicotine, and CO in mainstream cigarette smoke using a   machine-smoking protocol that does not reflect human smoking   behavior. Toxicity of smokeless tobacco products has not been   regularly monitored. Tobacco products are constantly changing and   untested products are introduced into the marketplace with great   frequency, including potential reduced-exposure products (PREPs).   The public health impact of new or modified tobacco products is   unknown. CONCLUSIONS: Systematic surveillance is recommended for   mainstream smoke constituents such as polycyclic aromatic   hydrocarbons (PAH), tobacco-specific nitrosamines (TSNA), total   and free-base nicotine, volatile organic compounds, aromatic   amines, and metals; and design attributes including tobacco   blend, additives, and filter ventilation. Research on smoking   topography is recommended to help define machine-smoking   protocols for monitoring emissions reflective of human smoking   behavior. Recommendations are made for marketplace product   sampling and for population monitoring of smoking topography,   emissions of toxic constituents, biomarkers of exposure and,   eventually, risk of tobacco-related diseases.

      Address (URL): http://www.ncbi.nlm.nih.gov/pubmed/18848577