Steven Stellman - Self-reported exposure to pesticides in residential settings and risk of breast cancer: a case-control study

Document created by Steven Stellman on Dec 1, 2016
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  Publication Details (including relevant citation   information):

  Farooq, U., Joshi, M., Nookala, V., Cheriyath, P., Fischman, D.,   Graber, N. J., Stellman, S. D., Muscat, J. 9 30-

  Abstract: BACKGROUND: Pesticides are widely used   in households to control insects and weeds. Several studies, over   the past decades, have examined the possible relationship of   serum concentration of organochlorine pesticides and the   development of breast cancer. However, little data exists   regarding an association between self-reported, residential   exposure to pesticides and breast cancer risk. We, therefore,   present a case-control study examining self-reported exposure to   household pesticides with regard to associated risk of breast   cancer. METHODS: This study was conducted in the area in and   around New York City, NY and included 1205 patients (447 cases   and 758 controls). Cases were defined as women with newly   diagnosed breast cancer or carcinoma in-situ, while controls   included women with benign breast diseases or those undergoing   non-breast related surgery. All patients were asked a series of   questions to determine their pesticide exposure, including the   type of pesticide, location of exposure (inside vs. outside the   home), who applied the pesticide (self vs. a professional) and   duration of pesticide use. Logistic regression models were used   to estimate unadjusted and adjusted odds ratios (OR) and   corresponding 95% confidence intervals (CI). RESULTS: The most   common pests encountered in participants' homes were ants,   carpenter ants, and cockroaches. The calculated adjusted odds   ratios for both self and professionally applied pesticides,   specifically against the above mentioned insects, with regard to   breast cancer risk were 1.25 (95% CI: 0.79-1.98) and 1.06 (95%   CI: 0.65-1.73), respectively. Similarly, odds ratios and   confidence intervals were calculated for other types of   pesticides. CONCLUSIONS: Overall, the results of our study did   not show an association between self-reported exposure to   pesticides and breast cancer risk. Future studies, utilizing a   larger sample size and more specific detail on time frame of   pesticide exposure, are needed to further explore this question.

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