Steven Stellman - Nicotine dependence phenotype, time to first cigarette, and risk of head and neck cancer

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      Publication Details (including relevant citation   information):

      Muscat, J. E., Ahn, K., Richie, J. P., Jr., Stellman, S. D.   117 (23) 5377-82-

      Abstract: BACKGROUND: A behavioral phenotype   that characterizes nicotine dependence, the time to first   cigarette after waking, is hypothesized to increase the risk of   head and neck cancer. METHODS: A case-control study of   histologically confirmed head and neck cancer was conducted that   included 1055 cases and 795 controls with a history of cigarette   smoking. RESULTS: The pack-years-adjusted odds ratio was 1.42   (95% confidence interval [95% CI], 1.02-1.99) for an interval of   31 minutes to 60 minutes to first cigarette after waking and 1.59   (95% CI, 1.19-2.11) for an interval of 1 minute to 30 minutes.   The risk estimates were similar when smoking was modeled as total   years, smoking status (current vs former), number of cigarettes   smoked per day, years since quitting, and excess odds ratio.   Findings were consistent for cancers of the floor of the mouth,   palate, and pharynx. CONCLUSIONS: Time to first cigarette is an   indicator of increased nicotine dependence, smoke uptake, and   risk of head and neck cancer. This high-risk group of individuals   would benefit from targeted smoking interventions.

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