Steven Stellman - Nicotine dependence phenotype and lung cancer risk

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      Publication Details (including relevant citation   information):

      Muscat, J. E., Ahn, K., Richie, J. P., Jr., Stellman, S. D.   117 (23) 5370-6-

      Abstract: BACKGROUND: A behavioral phenotype   that characterizes nicotine dependence, the time to first   cigarette after waking, is hypothesized to increase the risk of   lung cancer. METHODS: A case-control study of histologically   confirmed lung cancer was conducted. The current analysis   included 4775 lung cancer cases and 2835 controls who were   regular cigarette smokers. RESULTS: Compared with subjects who   smoked their first cigarette > 60 minutes after waking, the   pack-years-adjusted odds ratio was 1.31 (95% confidence interval   [95% CI], 1.11-1.54) for subjects who smoked 31 minutes to 60   minutes after waking and 1.79 (95% CI, 1.56-2.07) for subjects   who smoked within 30 minutes of waking. The risk estimates were   similar when smoking was modeled as total years, smoking status   (current vs former), number of cigarettes smoked per day, years   since quitting, and excess odds ratio. The findings were   consistent for all histologic types of lung cancer. CONCLUSIONS:   The findings of the current study indicate that a specific   nicotine dependence phenotype that is associated with the amount   of smoke uptake per cigarette is independently associated with   lung cancer risk. These findings may help to identify high-risk   individuals who would benefit from targeted interventions.

      Address (URL): http://www.ncbi.nlm.nih.gov/pubmed/21826644