Steven Stellman - The nicotine dependence phenotype, time to first cigarette, and larynx cancer risk

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      Publication Details (including relevant citation   information):

      Muscat, J. E., Liu, H. P., Livelsberger, C., Richie, J. P., Jr.,   Stellman, S. D. 23 (3) 497-503-

      Abstract: PURPOSE: Cigarette smoking is the   major cause of laryngeal cancer. The time to first cigarette   after waking in the morning is a behavior associated with several   dimensions of nicotine dependence including the dose of smoke   uptake. We hypothesized that a short TTFC increases the risk of   laryngeal cancer. METHODS: The analysis was based on data from a   hospital-based case-control study of laryngeal cancer. The   current analysis included only subjects who were ever cigarette   smokers, including 570 cases and 343 controls (832 whites and 81   blacks). Odds ratios (OR) and 95% confidence intervals (CI) were   calculated using unconditional logistic regression adjusting for   smoking history and other potential confounders. Incidence data   from the Surveillance, Epidemiology, and End Results (SEER)   Program of the National Cancer Institute from 1975 to 2006 were   analyzed for trends in laryngeal cancer. RESULTS: There was a   dose-response relationship between TTFC and supraglottic cancer.   Compared to subjects who smoked more than 60 min after waking,   the adjusted odds ratio was 1.51 (95% CI, 0.63-3.61) for 30-60   min and 3.13 (95% CI, 1.56-6.30) for 0-30 min. No association was   observed between TTFC and cancer of the glottis. In blacks, the   TTFC was not associated with the risk of laryngeal cancer. Trends   in SEER rates were similar for cancer of the glottis and   supraglottis, indicating that the site-specific differences were   not affected by unknown confounders. CONCLUSION: A nicotine   dependence behavior that is associated with cigarette smoke   uptake increases the risk of cancer of the supraglottis larynx,   but not glottis larynx.

      Address (URL): http://www.ncbi.nlm.nih.gov/pubmed/22367700