Steven Stellman - Exposure to fogger trucks and breast cancer incidence in the Long Island Breast Cancer Study Project: a case-control study

Document created by Steven Stellman on Dec 1, 2016
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  White, A. J., Teitelbaum, S. L., Wolff, M. S., Stellman, S. D.,   Neugut, A. I., Gammon, M. D. 12 24-

  Abstract: BACKGROUND: Few studies have supported   an association between breast cancer and DDT, usually assessed   with biomarkers that cannot discern timing of exposure, or   differentiate between the accumulation of chronic low-dose versus   acute high-dose exposures in the past. Previous studies suggest   that an association may be evident only among women exposed to   DDT during biologically susceptible windows, or among those   diagnosed with estrogen receptor/progesterone receptor-positive   (ER+PR+) breast cancer subtypes. Self-reported acute exposure to   a fogger truck, which sprayed DDT prior to 1972, was hypothesized   to increase the risk of breast cancer, particularly among women   exposed at a young age or diagnosed with ER+PR+ breast cancer.   METHODS: We examined these possibilities in the Long Island   Breast Cancer Study Project (LIBCSP) (1,508 cases, 1,556   controls), which included exposure assessment by structured   questionnaire and serum samples collected between 1996-1998,   using adjusted logistic and polytomous regression to estimate ORs   and 95% CIs. RESULTS: Women with ER+PR+ breast cancer had a 44%   increased odds of ever seeing a pre-1972 fogger truck compared to   other subtypes (OR = 1.44; 95% CI 1.08-1.93). However, there was   little variation in the observed increase in breast cancer risk   when considering all women who reported seeing a pre-1972 fogger   truck at their residence (OR = 1.16; 95% CI 0.98, 1.37), or   during hypothesized susceptible windows. Self-reported acute   exposure was not correlated with serum concentrations, a   biomarker of long-term exposure. CONCLUSIONS: These findings   support the hypothesis that seeing a fogger truck, a proxy   measure for acute DDT exposure, may be associated with ER+PR+   tumors, the most commonly diagnosed breast cancer subtype among   American women.

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